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Computer aided learning for quantitative genetics.

Written by Brian Kinghorn with some contributions form Roddy Vagg, John Woolliams, Julius van der Werf, and Sandy Kinghorn, plus translators to other languages.


GENUP contains a number of learning modules. Each of these is designed to help you master concepts in Quantitative Genetics and its application to Animal Breeding. These modules are largely algorithm-based rather than information-based, meaning that you are given opportunities to play with the properties of the subject rather than be given information about the subject. The program runs under Microsoft Windows 95/98/NT.

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(Note:  These extracts are far from fully descriptive - the GENUP help file gives full descriptions)

DIVERSITY:  The genetic distance cluster diagram (left) is calculated from genetic marker information for a number of populations.   Results for the current conservation solution are shown in the center - the solution, shown elsewhere, is the number of individuals to be chosen from each population.   The graph on the right shows the domain of possible combinations of mean merit and genetic variance.  Clicking on this graph (to give a green circle) causes a genetic algorithm to find the nearest solution (small white circle).

Description: Description: Description: diversity.gif (15340 bytes)

PopQTL: This module draws on parameters in the core database to generate a population with overlapping generations. This foundation population is then propagated according to the chosen genetic evaluation method.  A single QTL segregates, and QTL genotype can be known (or not known) if desired.  This picture shows the default graphic output.  Red dots are males and blue dots are females.  Axes can be changed with one or two clicks, covering all four traits.

Description: Description: Description: PopQTL.gif (11797 bytes)

SEL:  This module provides a graphical presentation of a very simple selection program. Users can discover how key parameters affect selection response.  This is an example with Spanish selected as the language option

Description: Description: Description: C:\Users\Brian\Documents\My Web Sites\bpk\sel_sp.gif


Some version changes



Module DIVERSITY added.  Pop*** graphs bug for low pop size fixed.  Bugs in 4.7 alone - missing tick in SEL graphs, and missing exercise files re-instated.  From 21 June 1999: Missing file hdk3anim.dll reinstated.



Module ELLIPSE upgraded.  Distribution error in Diversity fixed.



Module DESIRE added (see Desire). Population sizes in popsim modules > 2^15 now allowed. Economic wts in Editcore now limited to 5 digits. Red line in Ellipse Econlines.
Some file path bugs fixed. Bug in reading in old POP simulation files fixed.



Genetic variation within population fixed in Diversity - was 2x correct value. Incorrect pm in AGES fixed. Ages options for whole numbers and finite selection intensities.  Language internationalisation added, thanks to David Wright (technical development) and FAO (sponsorship).  English is the only language available at this stage. 



Spanish translation completed by Leo Alfonso.  Minor bug fixes.  Volunteers for other languages - please email me (  NB:  The help file has not been translated - this is still in English.



PopSim modules now allow up to 2,147,483,647 animals.  Exercise files now open in Microsoft Word if it is available.  Error in Module Loops fixed.  Italian translation completed by Roberto Leotta with assistance from Francesca Cecchi and Marco Bagliacca.  Portuguese translation completed by Cedric Gondro.  Various other bug fixes.



Zero heritability bug in Popsim modules fixed.



Turkish translation by M. İhsan SOYSAL.

Downloading GENUP

Download and save it in an empty directory on your hard disk (you can delete this directory and all its files after installation). It is a good idea to uninstall any older version of GENUP, before proceeding.  If you have a capable program such as WinZIP, you can execute SETUP.EXE directly.  Otherwise unzip the file.  If you do not have an unzipper, you can download pkunzip.exe, into the same directory, and then run:

pkunzip     at the DOS prompt.

Three files will be produced. Run the file SETUP.EXE and follow instructions. [NB. You may be told that some system files need updating.  This is done by Microsoft, whose VB6 compiler was used for making GENUP.  In this case you will need to re-run SETUP.EXE after updating your system files.  If you have a problem, go to;EN;q191096].  After installation, a start menu item which runs the installed program will result.

Use the program Help menus to get started. If you have problems viewing the help files go to and download the Windows Help program (WinHlp32.exe) for your Windows operating system. The navigation pane on the left side of the help window is only operable on Windows XP and previous versions - you will get a message on later versions 'There was a problem running the macro' [One day I will make a new Genup!!].

Good Luck!

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