Metabolism

8/11/03

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Table of Contents Metabolism Overview Citric acid cycle (Krebs cycle) Acetyl-coenzyme A ADPATP ADPATP ADPATP NAD+NADH NAD+NADH NAD+NADH FADFADH2 FADFADH2 FADFADH2 Catabolism of fats Catabolism of fats PPT Slide Catabolism sugars PPT Slide PPT Slide PPT Slide Catabolism of proteins PPT Slide Catabolism of proteins PPT Slide Citric acid cycle PPT Slide Citric acid cycle PPT Slide Citric acid cycle PPT Slide Citric acid cycle Citric acid cycle Electron transport-ATP synthesis Electron transport-ATP synthesis Anabolism of fats - an example of biological synthesis Anabolism of fats Anabolism of fats Anabolism of fats Pathways to drug metabolism Phase I metabolism Action of mixed function oxidases (cytochrome P450) Aromatic and aliphatic hydroxylation Epoxidation Dealkylation of amines, thioethers Dealkylation of amines, thioethers Dealkylation of amines, thioethers Deamination and alcohol oxidation N-Oxidation/hydroxylation Oxidation without cytochrome P450 NAD+ oxidation of aldehydes Other non P450 oxidases FAD aromatisation Reductive metabolism Reduction of an azo group Sulfa drugs Action of sulfanilamide Reduction of nitro compounds Reduction of ketones Hydrolysis of esters and amides Epoxides can be hydrated Phase II metabolism Glucuronidation Glucuronidation Examples of glucuronidation Examples of glucuronidation Reduction of nitro compounds Sulfate ester formation PAPS Example of sulfation Example of sulfation Methylation and acetylation Methylation (SAM) Acetylation (Acetyl-CoA) Amino acid conjugation Glutathione conjugation Glutathione conjugation Glutathione conjugation Glutathione can reduce electrophiles Metabolism of Prontosil Metabolism of Paracetamol Endogenous metabolism Metabolism of lipids Lipid metabolism Lipid metabolism Lipid metabolism Lipid metabolism Lipid metabolism Metabolism of lipids Metabolism of lipids Metabolism of fatty acids Metabolism of fatty acids Non-MFO endogenous oxidations Metabolism of purines Metabolism of purines Phase II metabolism Methylation with methionine Glutathione conjugates

Author: Steve Glover Email: sglover@metz.une.edu.au Home Page: http://www.une.edu.au/chemistry/research/glover.html Other information: These slides are not animated as they are in lectures. This material may only be reproduced with the express approval of the author. Slides are aids to the material in Chaper 2 of the CHEM303 module notes. Return to main index