Methylation and acetylation

• Methylation and acetylation do not improve solubility

• Rather they reduce pharmacological activity

• Methylation ó S-adenosylmethionine (SAM)

  • amines, thiol, alcohols

• Acetylation ó Acetyl CoA

  • Amines (óNH2), amides (-CONH2), hydrazines (óNH2NH2ó)

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